Prozac Research Today is a free monthly online journal that collates and summarizes the latest research about Prozac, including details on depression, side-effects, withdrawal, alternatives.

Response rates to fluoxetine in subjects who initially show no improvement.

Posternak MA, Baer L, Nierenberg AA, Fava M

Comprehensive Psychiatric Associates, 372 Washington St, Wellesley, MA 02481, USA. maposternak@yahoo.com

Published 9 August 2011 in J Clin Psychiatry, 72(7): 949-54.
Full-text of this article is available online (may require subscription).

Articles on Prozac published 29 July 2011:

Trace analysis of fluoxetine and its metabolite norfluoxetine. Part I: development of a chiral liquid chromatography-tandem mass spectrometry method for wastewater samples.   J Chromatogr A, 1218(33): 5587-96.

An enantioselective method for the determination of fluoxetine (a selective serotonin reuptake inhibitor) and its pharmacologically active metabolite norfluoxetine has been developed for raw and treated wastewater samples. The stable isotope-labeled fluoxetine and norfluoxetine were used in an extended way for extraction recovery calculations at trace level concentrations in wastewater. Wastewater samples were enriched by solid phase extraction (SPE) with Evolute CX-50 extraction cartridges. ... [Abstract] [Full-text]

Articles on Prozac published 14 July 2011:

Juvenile administration of concomitant methylphenidate and fluoxetine alters behavioral reactivity to reward- and mood-related stimuli and disrupts ventral tegmental area gene expression in adulthood.   J Neurosci, 31(28): 10347-58.

There is a rise in the concurrent use of methylphenidate (MPH) and fluoxetine (FLX) in pediatric populations. However, the long-term neurobiological consequences of combined MPH and FLX treatment (MPH + FLX) during juvenile periods are unknown. We administered saline (VEH), MPH, FLX, or MPH + FLX to juvenile Sprague Dawley male rats from postnatal day 20 to 34, and assessed their reactivity to reward- and mood-related stimuli 24 h or 2 months after drug exposure. We also assessed mRNA and ... [Abstract] [Full-text]

Articles on Prozac published 29 June 2011:

Fluoxetine inhibits NF-κB signaling in intestinal epithelial cells and ameliorates experimental colitis and colitis-associated colon cancer in mice.   Am J Physiol Gastrointest Liver Physiol, 301(1): G9-19.

Although fluoxetine, a selective serotonin reuptake inhibitor, is known to demonstrate anti-inflammatory activity, little information is available on the effect of fluoxetine regarding intestinal inflammation. This study investigates the role of fluoxetine in the attenuation of acute murine colitis by suppression of the NF-κB pathway in intestinal epithelial cells (IEC). Fluoxetine significantly inhibited activated NF-κB signals and the upregulated expression of interleukin-8 (IL-8) in COLO ... [Abstract] [Full-text]

Articles on Prozac published 24 June 2011:

Infant maternal separation impairs adult cognitive performance in BALB/cJ mice.   Psychopharmacology (Berl), 216(2): 207-18.

[Abstract] [Full-text]

Articles on Prozac published 21 June 2011:

Selective serotonin reuptake inhibitors and risk for major congenital anomalies.   Obstet Gynecol, 118(1): 111-20.

[Abstract] [Full-text]

Articles on Prozac published 9 June 2011:

Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice.   Behav Brain Res, 223(1): 125-34.

Endocannabinoid analogues exhibit antidepressant and anti-compulsive like effects similar to that of serotonin selective reuptake inhibitors (SSRIs) indicating a parallelism between the effects of serotonin and endocannabinoids. Therefore, the present study was designed to investigate the role of endocannabinoids in the antidepressant and anti-compulsive like effect of fluoxetine using mice model of forced swim test (FST) and marble-burying behavior (MBB). The results revealed that ... [Abstract] [Full-text]

Articles on Prozac published 6 June 2011:

Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats.   Toxicol Lett, 204(2): 134-40.

Fluoxetine (FLX) is a drug commonly used as antidepressant. However, its effects on tumorigenesis remain controversial. Aiming to evaluate the effects of FLX treatment on early malignant changes, we analyzed serotonin (5-HT) metabolism and recognition, aberrant crypt foci (ACF), proliferative process, microvessels, vascular endothelial growth factor (VEGF), and cyclooxygenase-2 (COX-2) expression in colon tissue. Male Wistar rats received a daily FLX-gavage (30mgkg(-1)) and, a single dose of ... [Abstract] [Full-text]

Articles on Prozac published 27 May 2011:

Effects of fluoxetine and LY 367265 on tolerance to the analgesic effect of morphine in rats.   Acta Physiol Hung, 98(2): 205-13.

Morphine is widely used to treat chronic pain, however its utility is hindered by the development of tolerance to its analgesic effects. The aim of this study was to investigate effects of fluoxetine, a specific serotonin (5-HT) reuptake inhibitor, and LY 367265, an inhibitor of the 5-HT transporter and 5-HT2A receptor antagonist, on tolerance induced to the analgesic effect of morphine in rats. The study was carried out on male Wistar Albino rats (weighing 170-190 g). To constitute morphine ... [Abstract] [Full-text]

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